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. 2011 Apr;337(1):9–15. doi: 10.1124/jpet.110.175380

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Fig. 3. — MMP-2 protein and activity levels in MCAs from diabetic and control MCAs. A, MMP-2 protein was elevated in diabetes and was restored to control levels by ET receptor blockade. Representative immunoblot is shown below the histogram. B, MMP-2 activity was also greater in diabetes and reduced to control levels by either treatment. It is noteworthy that A192621 increased MMP-2 activity in control animals without a change in protein levels. A representative zymogram is shown below the histogram. C, Levels of TIMP-2 protein, endogenous MMP-2 inhibitor, were not different among groups. Results are given as mean ± S.E.M., n = 6–8 in all groups except control + A192621 = 3. *, p < 0.05 versus control. **, p = 0.0005 disease and treatment interaction. #, p < 0.05 versus diabetes.