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. 2011 Apr;337(1):9–15. doi: 10.1124/jpet.110.175380

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Fig. 4. — Differential effect of ET receptor antagonism on MMP-13 and collagen levels in control and diabetic animals. A, MMP-13 protein was decreased in diabetes and was restored to control levels by either ET receptor blockade. Selective ETB receptor blockade with A192621 but not bosentan reduced MMP-13. B, ET receptor antagonism prevented the increase in collagen type 1 in diabetes, but selective ETB blockade caused an increase in control animals. Results are given as mean ± S.E.M., n = 6–8 in all groups except control + A192621 = 3. *, p < 0.05 versus control vehicle. **, p = 0.0039 disease and treatment interaction. ***, p = 0.0001 disease and treatment interaction.