TABLE 1.

Physiological parameters of animal groups

Results are given as mean ± S.E.M.

	Control			Diabetes
	Vehicle (n = 11)	A192621 (n = 3)	Bosentan (n = 8)	Vehicle (n = 11)	A192621 (n = 8)	Bosentan (n = 8)
Body weight, g	485 ± 16	406 ± 2#	418 ± 7#	352 ± 6*	320 ± 5*#	333 ± 5*#
Systolic blood pressure, mm Hg	129 ± 5	159 ± 5#	142 ± 6	142 ± 3	157 ± 6#	157 ± 6
Diastolic blood pressure, mm Hg	92 ± 3	100 ± 4#	95 ± 5	89 ± 5	100 ± 5#	96 ± 3
Blood glucose, mg/dl	108 ± 4	104 ± 5	93 ± 9	161 ± 17*	152 ± 8*	194 ± 27*

^#P < 0.0001 vs. vehicle;

^*P < 0.0001 vs. control.