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. 2011 Mar 24;7(3):e1002032. doi: 10.1371/journal.pgen.1002032

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Sekerková et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A–H) Stereocilia on inner hair cells in the middle and apical cochlear regions of +/je mice show obvious tapering along their proximal-distal axis (B,D). This tapered segment becomes mostly (F) or partly (H) filled in by P10. The tapering is not observed for the stereocilia of +/+ mice (A,E,C,G). Black outlines highlight examples (kinocilium, arrow). (I-L) In the extreme apex (>95% from base), proximal-distal tapering of stereocilia is evident in +/je mice at P20 (J,K), but not in +/+ control mice (I), and can still be seen at 8 months (L). Scale bars, 1 µm (A-J,L) or 2 µm (K).