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. 2011 Mar 24;7(3):e1002028. doi: 10.1371/journal.pgen.1002028

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Ameur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Mitochondrial genome position (x-axis) versus sequence coverage divided by maximum coverage for each sample. The coverage was calculated using a 2 kb sliding window average. The red lines correspond to mtDNA mutator samples. All other mouse samples are in black. The blue line represents the sequence coverage of the λ^mtDNA control. The approximate locations of the origins of light-strand (O_L) and heavy-strand (O_H) replication are indicated by dotted lines with arrows.