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. 2011 Mar 24;6(3):e14767. doi: 10.1371/journal.pone.0014767

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Holder et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Parameter region where the parameter values are most consistent with the experimentally-measured values of the plaque velocity (A and D), the exponential viral titer growth rate (B and E), and with both measures (C and F), for the A/Brisbane/59/2007 (H1N1) WT (first row) and H275Y mutant (second row) strains. Darker shading represents parameters more consistent with the experimental measures and two contour lines in each plot indicate the one and two standard deviation values (see Materials and Methods for details of this calculation).