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. 2011 Mar 24;6(3):e18204. doi: 10.1371/journal.pone.0018204

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von Kleist et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Switching times for changing from inducer- to maintenance therapy were automatically determined and carried out (using eq. (1)). The 0.5th percentile, marked by the red line, was determined and the corresponding time days was used as a fixed value in the suggested strategy to switch from inducer- to maintenance therapy. Hybrid deterministic-stochastic simulations were performed at clinically relevant parameter sets (see Table S1). Drug switches occurred in a total of 5478 out of 6000 simulations.

Inline graphic — Switching times for changing from inducer- to maintenance therapy were automatically determined and carried out (using eq. (1)). The 0.5th percentile, marked by the red line, was determined and the corresponding time days was used as a fixed value in the suggested strategy to switch from inducer- to maintenance therapy. Hybrid deterministic-stochastic simulations were performed at clinically relevant parameter sets (see Table S1). Drug switches occurred in a total of 5478 out of 6000 simulations.