Table 4.

Summary of the computing resources required by each method.

Software	Time taken (mins)	Peak memory usage (GB)
GenomeStudio (v 1.1.0)*	230	0.75
GenoSNP†	370⋄	0.09
Illuminus†	38⋄	12.2
CRLMM (v 1.2.4)†	28	38.2

These figures are based on the analysis of a set of 346 samples (batch 2) from the MS-GWAS.

* run on a PC (Pentium quad core, 3 Ghz computer with 2 GB RAM) with file-based storage enabled

^† run on a quad-core AMD Opteron 2.7 Ghz CPU linux machine with 64 GB RAM

^⋄ timing does not include time taken by GenomeStudio to output X and Y data used as input for these methods (30 mins and 0.65 GB RAM on the PC we used)