Skip to main content
. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Apr;70(4):281–291. doi: 10.1097/NEN.0b013e31821284e9

Figure 8.

Figure 8

Isoflurane modulates key components of the RhoA signaling cascade. Isoflurane-induced actin cytoskeleton-mediated disturbances of glial morphological transformation and growth are associated with modulation of the RhoA/MLC-mediated cascade. Substantial downregulation of endogenous RhoA and myosin light chain/phosphorylated myosin light chain (MLC/MLC-P) coincides with significant downregulation of endogenous paxillin and disturbances in glial growth, morphological transformation, and the formation of actin stress fibers (ASF).

HHS Vulnerability Disclosure