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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Nov 11;51(4):534–541. doi: 10.1016/j.yjmcc.2010.11.005

Figure 2. β1AR-mediated transactivation of EGFR and direct ligand stimulation of EGF R differentially target ERK.

Figure 2

Wild type β1AR cells expressing EGFR-GFP and ERK2-RFP were stimulated for 20 min with Dobutamine or Epidermal Growth Factor (EGF). EGFR-GFP underwent internalization in response to Dobutamine or EGF (panels 3 and 5, arrowheads), which was blocked by the EGFR inhibitor AG1478 (panels 7 and 9). Only EGF induced nuclear translocation of ERK2-RFP (panel 6, arrow), which was prevented by AG1478 (panel 10). Reproduced with permission from Ref [45].