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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Nov 11;51(4):534–541. doi: 10.1016/j.yjmcc.2010.11.005

Figure 5. The carboxyl terminus of β1-AR but not β2-AR is necessary for CaMKII activation and conformational changes of β-arrestin.

Figure 5

A) Using βAR chimeras (i.e. β2AR with β1AR c-terminal tail), YFP-β arrestin2-Luc biosensor and measuring bioluminescence resonance energy transfer (BRET), Mangmool et al. show that the C-tail of the β1AR is the key regulatory component that promotes unique β- arrestin conformation. B) The c-terminal of the β1AR also plays a key role in promoting β arrestin mediated CAMKII signaling upon ligand stimulation. (Reproduced with permission from [13]).