Table I.
Overview of the Internal Dataset (Int.1) and the External Datasets (Ext.1–5) Used for Model Building and External Model Evaluation
| Dataset | Patient population | Number of patients | Postnatal age in days (median, IQR) | Body-weight in g (median, IQR) |
|---|---|---|---|---|
| Int.1.(6) | Post-operative term neonates, infants and children. | 183 | 97 (8–286) | 4,700 (3,100–8,000) |
| Ext.1.(9) | Post-operative term neonates and infants | 28 | 14 (0–70) | 3,100 (2,550–4,000) |
| Ext.2.(10) | Post-operative term neonates and infants | 9 | 10.5 (3–135) | 3,800 (3,000–5,000) |
| Ext.3.(11) | Term neonates and infants on artificial ventilation | 12 | 13 (6–80) | 3,050 (2,675–6,900) |
| Ext.4.(7) | Preterm and term neonates on artificial ventilation | 63 | 0.4 (0.2–0.5) | 1,180 (862.5–1,760) |
| Ext.5.(8) | Preterm neonates on artificial ventilation | 41 | 1 (1–2) | 1,035 (892.5–1,295) |
Int. internal dataset, Ext. external dataset, M morphine, M3G morphine-3-glucuronide, M6G morphine-6-glucuronide