Table IV.
Bias (MPE) and Precision (RMSE) of the Predicted Parameter Values in the Internal Datasets Stratified by Age Group
| Parameter | Age group | Systematic covariate model | Fixed allometric model | ||
|---|---|---|---|---|---|
| MPE | RMSE | MPE | RMSE | ||
| Total morphine clearance | neonatesa | 4.26 | 0.426 | 10.8 | 0.922 |
| toddlersb | -0.74 | 1.65 | 12.7 | 5.00 | |
| infantsc | 4.63 | 3.28 | -2.56 | 7.90 | |
| M3G clearance | neonatesa | 19.7 | 0.291 | -19.5 | 2.50 |
| toddlersb | 1.85 | 0.888 | 23.8 | 15.5 | |
| infantsc | 14.5 | 3.82 | 188 | 9.03 | |
| M6G clearance | neonatesa | 12.5 | 0.0784 | -69.0 | 0.825 |
| toddlersb | 0.262 | 0.230 | 100 | 5.27 | |
| infantsc | 4.93 | 0.852 | 253 | 2.84 | |
| Distribution volume of central morphine compartment | neonatesa | 23.2 | 1.30 | 90.6 | 2.93 |
| toddlersb | 15.9 | 3.43 | 22.4 | 7.26 | |
| infantsc | 5.90 | 9.27 | 9.35 | 13.4 | |
MPE mean prediction error, RMSE root mean square error
aneonates, PNA <30 days, n = 61
btoddlers, PNA = 1 month-1 year, n = 87
cinfants, PNA >1 year n = 35