Table V.
Bias (MPE) and Precision (RMSE) of the Predicted Parameter Values in the External Datasets Stratified by Age Group
| Parameter | Age Group | Systematic covariate model | Fixed allometric model | ||
|---|---|---|---|---|---|
| MPE | RMSE | MPE | RMSE | ||
| Total morphine clearance | preterm neonatesa | 17.4 | 0.0667 | 192 | 0.444 |
| term neonatesb | 29.74 | 0.274 | 85.5 | 3.91 | |
| toddlersc | 29.3 | 1.64 | -26.6 | 4.22 | |
| M3G clearance | preterm neonatesa | -16.3 | 0.102 | 114 | 0.225 |
| term neonatesb | 31.0 | 0.463 | 108 | 0.928 | |
| toddlersc | 5.48 | 0.818 | 172 | 1.34 | |
| M6G clearance | preterm neonatesa | -12.5 | 0.0447 | 46.8 | 0.779 |
| term neonatesb | 35.6 | 0.0818 | 31.1 | 0.502 | |
| toddlersc | 12.5 | 0.285 | 93.5 | 0.490 | |
| Distribution volume of central morphine compartment | preterm neonatesa | -12.9 | 0.945 | -115 | 1.46 |
| term neonatesb | -10.3 | 2.03 | -296 | 3.50 | |
| toddlersc | 3.45 | 3.47 | -93.1 | 3.22 | |
MPE mean prediction error, RMSE root mean square error
apreterm neonates, (PNA <30 days and PMA at birth <36 weeks), n = 80
bterm neonates, (PNA <30 days and PMA at birth ≥36 weeks), n = 40
cinfants, PNA = 1 month–1 year,n = 33