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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Cancer Res. 2010 Jul 14;70(15):6283–6292. doi: 10.1158/0008-5472.CAN-10-0412

Figure 6. Reduction in tumor hypoxia reduces CA9 expression and gene expression related drug resistance and ‘stemness’.

Figure 6

KP-1N xenografts were treated with or without intravenous administration of cultured VPC (105 cells for 3 times) and mice were sacrificed 2 weeks after the procedure. (A) Xenograft tissues were stained with anti-CA9 either in peri-necrotic (upper panel) or in viable area (lower panel). Quantification of CA9 positive cells is shown in 5 viable fields from 6 sections. Scale bars; 500 μm. “N” indicates necrotic area. (B) RNA was extracted from xenograft tissue and mRNA levels of CA9, Oct-4, hENT1, dCK, MDR-1 (ABCB1) and ABCG2 in cancer cells in xenografts were analyzed by TaqMan qPCR.