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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: Gastroenterology. 2010 Mar 27;139(1):259–69.e3. doi: 10.1053/j.gastro.2010.03.045

Figure 4.

Figure 4

Purified TcdA and TcdB increase HIF-1α protein and DNA binding. (a) Caco-2 cells were exposed to purified TcdA (100ng/mL, 500ng/mL) and TcdB (10ng/mL, 100ng/mL) for 4h. Western blot is representative of four experiments (ab6489). (b) DNA binding of HIF-1α to the EPO HRE in Caco-2 cells exposed to CoCl2 (100µM) or purified TcdA (100ng/mL) and TcdB (100ng/mL).