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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: Gastroenterology. 2010 Mar 27;139(1):259–69.e3. doi: 10.1053/j.gastro.2010.03.045

Figure 6.

Figure 6

Targeted deletion of HIF-1α in intestinal epithelium augments C.difficile toxin-induced inflammation. (a) Tissue inflammation as assessed by MPO levels in ileum isolated from wild-type I29 and HIF-1α epithelial-targeted knockout (HIF-1α−/−) mice treated with C.difficile toxin (100µg), *p<0.05 compared to wild-type I29, n=6. (b) Serum NO levels were assessed from wild-type I29 and HIF-1α epithelial-targeted knockout (HIF-1α−/−) mice treated with C.difficile toxin (100µg), *p<0.05 compared to wild-type I29, n=6. (c) H&E stained ileal sections from HIF-1α−/− (top row) and wild-type I29 (bottom row) following 4h exposure to C.difficile toxin (100µg).