Figure 5.
The effects of U-73122 on the prostaglandin F2α-induced response in pacemaker currents of cultured interstitial cells of Cajal from mouse small intestine. A: U-73122 (5 μmol/L) abolished the generation of pacemaker currents. U-73122 also blocked the Prostaglandin F2α (PGF2α) (10 μmol/L)-induced tonic inward currents. The dotted lines indicate the zero current levels. Responses to the PGF2α are summarized in B. Vertical solid line scales denote amplitude of pacemaker current and horizontal solid line scales denote duration of recording (s) pacemaker current. The bars represent mean ± SE. The effect of U-73122 on PGF2α-induced pacemaker currents was significantly different from the PGF2α-induced pacemaker currents in the absence of U-73122 (bP < 0.01).