Table 1.
Relation between clinicopathological features and immunohistochemical staining of CD133 in cholangiocarcinoma specimens
| Variable | Total(n = 34) |
CD133 expression |
P-value | |
| Weak | Strong | |||
| Age | ||||
| < 60 | 18 | 7 | 11 | 0.477 |
| > 60 | 16 | 4 | 12 | |
| Sex | ||||
| Male | 22 | 8 | 14 | 0.705 |
| Female | 12 | 3 | 9 | |
| Tumor differentiation | ||||
| Well | 17 | 7 | 10 | 0.465 |
| Moderate/poor | 17 | 4 | 13 | |
| Node | ||||
| Negative | 16 | 9 | 7 | 0.0091 |
| Positive | 18 | 2 | 16 | |
| Distant metastasis | ||||
| Negative | 24 | 10 | 14 | 0.113 |
| Positive | 10 | 1 | 9 | |
| Surgical resection margin2 | ||||
| R0 | 20 | 10 | 10 | 0.0111 |
| R1, R2 | 14 | 1 | 13 | |
| Location of tumor | ||||
| Perihilar | 12 | 3 | 9 | 0.705 |
| Intrahepatic | 22 | 8 | 14 | |
| Neurovascular invasion3 | ||||
| Positive | 15 | 8 | 7 | 0.210 |
| Negative | 9 | 2 | 7 | |
1
Statistically significant;
2
Surgical resection margin: R0 = negative resection margin, R1 = microscopic positive resection margin and R2 = macroscopic positive resection margin;
3
To study the presence of neurovascular invasion, we excluded 10 specimens derived from tissue biopsy.