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. Author manuscript; available in PMC: 2011 Mar 25.
Published in final edited form as: Adv Exp Med Biol. 2010;676:27–55. doi: 10.1007/978-1-4419-6199-0_3

Figure 5. Regulation of cytokinesis by mitotic kinases.

Figure 5

A major function of CDK1 is to prevent precocious cytokinesis before proper chromosome segregation. CDK1 thus negatively regulates some of the main players of cytokinesis. At the same time, CDK1 plays a positive role in cytokinesis by releasing cytokinesis proteins from the Golgi apparatus, and by facilitating binding of Plk1 to its substrates. Plk1 and Aurora B phosphorylate substrates that are important for both early and late steps of cytokinesis. Solid arrows indicate phosphorylation; dashed arrows indicate changed protein localization; dotted arrows indicate protein interactions. IF, intermediate filaments.