Table 2.
Tuberculosis cases | Person-years | Incidence rate (95% CI) per 100 person-years | Incidence rate ratio (95% CI) | Hazard ratio (95% CI) | Adjusted hazard ratio (95% CI) | |
---|---|---|---|---|---|---|
Total | 267 | 4287 | 6.2 (5.5–7.0) | – | – | – |
Sex | ||||||
Female | 198 | 3468 | 5.7 (5.0–6.6) | REF | REF | REF |
Male | 68 | 814 | 8.3 (6.5–10.6) | 1.46 (1.09–1.94) | 1.46 (1.11–1.92) | 1.22 (0.91–1.62) |
Clinic location | ||||||
Urban | 192 | 3403 | 5.6 (4.9–6.5) | REF | REF | REF |
Rural | 75 | 883 | 8.5 (6.8–10.6) | 1.51 (1.13–1.98) | 1.51 (1.16–1.98) | 1.36 (1.02–1.81) |
Age at baseline visit (years) | ||||||
17–29 | 62 | 1325 | 4.7 (3.6–6.0) | REF | REF | REF |
30–39 | 125 | 1992 | 6.3 (5.3–7.5) | 1.34 (0.98–1.85) | 1.34 (0.98–1.82) | 1.35 (0.99–1.83) |
>39 | 80 | 965 | 8.3 (6.7–10.3) | 1.77 (1.26–2.51) | 1.77 (1.28–2.48) | 1.59 (1.12–2.26) |
CD4 cell count at baseline visit (cells/μl) | ||||||
<100 | 64 | 598 | 10.7 (8.4–13.7) | REF | REF | REF |
100–199 | 64 | 916 | 7.0 (5.5–8.9) | 0.65 (0.45–0.94) | 0.65 (0.46–0.93) | 0.68 (0.48–0.96) |
200–349 | 59 | 1125 | 5.2 (4.1–6.8) | 0.49 (0.34–0.71) | 0.49 (0.34–0.69) | 0.40 (0.27–0.57) |
>349 | 80 | 1649 | 4.9 (3.9–6.0) | 0.45 (0.32–0.64) | 0.45 (0.33–0.63) | 0.35 (0.24–0.50) |
IPT and HAART history | ||||||
Naive | 200 | 2815 | 7.1 (6.2–8.2) | REF | REF | REF |
HAART only | 44 | 952 | 4.6 (3.4–6.2) | 0.65 (0.46–0.91) | 0.62 (0.44–0.87) | 0.36 (0.25–0.51) |
IPT only | 22 | 427 | 5.2 (3.4–7.8) | 0.73 (0.44–1.13) | 0.71 (0.45–1.10) | 0.87 (0.55–1.36) |
IPT and HAART | 1 | 93 | 1.1 (0.2–7.6) | 0.15 (0.004–0.85) | 0.14 (0.02–1.03) | 0.11 (0.02–0.78) |
CI, confidence interval; HAART, highly active antiretroviral therapy; IPT, isoniazid preventive therapy.