Fig. 2.

The effects of other types of tyrosine kinase inhibitors (tyrphostin 23, tyrphostin 25, lavendustin A; A), orthovanadate (B), and inactive structural analogs (genistin, daidzein; C) on genistein-induced inhibition of Kv4.3. Representative superimposed currents were produced by applying 500-ms depolarizing pulses from a holding potential of −80 to +40 mV every 10 s. The control current, the currents recorded after preincubation with tyrphostin 23 and 25, and after a 10-min exposure to lavendustin A, orthovanadate, or inactive structural analogs, and the current measured after an additional 3-min treatment with 100 μM genistein are shown.