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. 2010 Dec 15;300(3):C550–C556. doi: 10.1152/ajpcell.00123.2010

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Fig. 4. — Proliferation and apoptosis. EC proliferation is influenced by microfibril preparations. A: cell count. Proliferation is increased in EC cultured on C57BL/6J microfibrils (first bar). EC proliferation is significantly reduced in EC cultured on microfibrils isolated from Tsk^−/+ mice (second bar). Proliferation is restored in EC cultured on microfibrils isolated from D-4F-treated Tsk^−/+ mice in culture media containing 10 μg/ml D-4F (third bar). Tsk^−/+ is significantly different (#P < 0.05) from both groups. B: MTS assay. Proliferation is increased in EC cultured on C57BL/6J microfibrils (first bar). EC proliferation is significantly reduced in EC cultured on microfibrils isolated from Tsk^−/+ mice (second bar). Proliferation is restored in EC cultured on microfibrils isolated from D-4F-treated Tsk^−/+ mice in culture media containing D-4F (10 μg/ml, third bar). Tsk^−/+ is significantly different (#P < 0.05) from C57BL/6J group. C: TUNEL. Percentage of apoptotic cells to viable endothelial cells is increased in cells seeded on Tsk^−/+ matrix. (7.8% of 100% viable cells) D: caspase-3 activity by FLICA (fluorochrome inhibitor of caspases) is increased in endothelial cells seeded on defective Tsk^−/+ matrix.