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Effect of MEK inhibitors on swelling- and shrinkage-induced changes in CLH-3b activity. Cells were swollen by exposure to a 200 mosM bath solution at −1 min. At time 0, cells were exposed to a 400 mosM bath solution to induce shrinkage. A and B: CLH-3b activation voltage and 50% rise time in cells expressing wild-type GCK-3. C: relative whole cell current in cells expressing KD or wild-type GCK-3. Values are means ± SE (n = 4–6). *P < 0.01 compared with control.
