Table 4.

Association of SNPs with mRNA expression levels^a

SNP	Position on chrom 4	Gene	MAF	GWAS ORb	SNCA (probe 29 939)		CTSD (probe 52 556)		GAK exon 26 (probe 155 700)		GAK exon 28 (probe 397 150)
					Beta	P-value	Beta	P-value	Beta	P-value	Beta	P-value
rs1564282	842,313	GAK	0.14 (T)	1.7	0.35c	0.003	−0.06	0.49	−0.12	0.16	−0.15	0.03
rs356229	90,825,620	3’ SNCA	0.44 (C)	1.35	−0.03	0.70	0.02	0.73	−0.01	0.87	−0.01	0.83
rs356188	90,910,560	SNCA	0.29 (C)	0.7	−0.08	0.27	0.12	0.007	0.11	0.02	0.07	0.1
rs3775478	91,061,863	MMRN1	0.12 (G)	1.7	0.05	0.67	0.04	0.55	−0.05	0.53	−0.04	0.56

MAF, minor allele frequency; Beta, beta coefficient.

^aAdjusted for PD/control, RIN, PMI and age at death.

^bOR previously reported for SNPs association to PD in our Familial PD GWAS (7) with P-values ranging from 5.9 × 10⁻⁶ to 8.4 × 10⁻⁵.

^ceSNP beta estimate in a subset of 32 brain samples with available ethnicity information (all Caucasians) was similar to the beta estimate value in the whole set of brains (Beta = 0.33).