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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: J Immunol. 2011 Feb 28;186(7):3874–3881. doi: 10.4049/jimmunol.1003231

Figure 5. Contribution of B7-mediated costimulation to IL-2 production by stable and inflationary memory populations of MCMV-specific CD8 T cells.

Figure 5

WT and B7.1/2−/− mice were infected with MCMV. At day 100 post-infection, MCMV-specific CD8 T cells were analyzed for intracellular expression of IFN-γ, TNF and IL-2 after restimulation with the indicated class I epitopes. Flow cytometry plots are gated on IFN-γ+ CD8 T cells and show the percentage of TNF and/or IL-2 production within this population. Graphs show the percentage of IL-2+ or TNF+ cells within the IFN-γ+ CD8 T cell population. Similar results were found at day 15 and day 40 post-infection. Statistical significance was determined by Student’s t test (* indicates p<0.05 and ** p<0.005). Bar graphs are shown as means with standard errors (n=5 per group). Data shown are representative of two independent experiments.