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Change in HbA1c in Cycloset (total group) and placebo-treated diabetic subjects. Cycloset responders (defined as a ≥0.3% decrease in HbA1c at week 8) had a significantly greater decline in HbA1c (placebo-subtracted ΔHbA1c = 1.0%) than the total group (ref. 29). SU, sulfonylurea. *P < 0.01; **P < 0.001; †P < 0.04 for Cycloset responders vs. total Cycloset group; ††P < 0.0001 for Cycloset responders vs. placebo.
