Table 1.
1st | 2nd | 3rd | 4th | P value | Age-corrected P value | |
---|---|---|---|---|---|---|
Patients (N) | 1,145 | 1,080 | 1,137 | 1,147 | — | — |
Sex (% women) | 42 | 50 | 58 | 56 | <0.001 | <0.001 |
Age (years) | 33 ± 9 | 36 ± 10 | 39 ± 12 | 47 ± 12 | <0.001 | — |
Duration (years) | 17 ± 9 | 19 ± 11 | 22 ± 12 | 30 ± 12 | <0.001 | <0.001 |
Age at onset (years) | 16 ± 11 | 17 ± 11 | 17 ± 11 | 17 ± 11 | 0.25 | <0.001 |
BMI (kg/m2) | 24.6 ± 3.7 | 24.8 ± 3.8 | 25.2 ± 3.5 | 25.5 ± 3.7 | <0.001 | 0.025 |
HbA1c (%) | 8.5 ± 1.7 | 8.4 ± 1.5 | 8.4 ± 1.4 | 8.5 ± 1.5 | 0.16 | 0.022 |
Total cholesterol (mmol/L) | 4.9 ± 1.0 | 4.9 ± 1.0 | 4.9 ± 1.0 | 5.2 ± 1.1 | <0.001 | <0.001 |
HDL cholesterol (mmol/L) | 1.6 ± 0.5 | 1.6 ± 0.5 | 1.6 ± 0.6 | 1.6 ± 0.5 | 0.49 | 0.073 |
LDL cholesterol (mmol/L) | 3.0 ± 0.8 | 3.0 ± 1.1 | 3.0 ± 0.9 | 3.2 ± 0.9 | <0.001 | 0.159 |
Triacylglycerol (mmol/L) | 1.02 (0.77–1.43) | 1.00 (0.75–1.41) | 1.04 (0.77–1.46) | 1.10 (0.81–1.58) | 0.03 | <0.001 |
Insulin dose (IU/kg) | 0.74 ± 0.26 | 0.72 ± 0.26 | 0.70 ± 0.25 | 0.66 ± 0.24 | <0.001 | 0.005 |
SBP (mmHg) | 118 ± 10 | 127 ± 10 | 136 ± 11 | 156 ± 16 | <0.001 | <0.001 |
DBP (mmHg) | 80 ± 9 | 80 ± 10 | 79 ± 10 | 79 ± 11 | 0.39 | 0.022 |
PP (mmHg) | 38 ± 5 | 48 ± 2 | 57 ± 3 | 76 ± 12 | <0.001 | <0.001 |
Mean arterial pressure (mmHg) | 80 ± 9 | 82 ± 10 | 85 ± 10 | 92 ± 11 | <0.001 | <0.001 |
History of CVD (%) | 4 | 6 | 7 | 19 | <0.001 | <0.001 |
History of smoking (%) | 47 | 45 | 47 | 50 | 0.109 | 0.241 |
Antihypertensive medication (%) | 24 | 28 | 38 | 62 | <0.001 | <0.001 |
eGFR (mL/min/1.73 m2) | 92 ± 30 | 93 ± 31 | 90 ± 34 | 87 ± 34 | <0.001 | <0.001 |
Diabetic nephropathy (%) | 13 | 15 | 20 | 40 | <0.001 | <0.001 |
Values are expressed as means ± SD, percent, or median (interquartile range).
eGFR, estimated glomerular filtration rate.