Table 2.

Validation of pediatric diabetes algorithms compared with clinical DER-CA registry, ascertainment rates, and ascertainment-corrected prevalence of youth-onset diabetes

No. years	Alg. #	n (DER-CA)	n (MCHP)	Ascertainment rate of DER-CA based on case definition	Ascertainment rate of repository for youth-onset diabetes	Ascertainment-corrected prevalence of youth-onset diabetes (per 1,000 youth)	κ	MCHP case definition algorithm
								Sens	Spec	PPV	NPV
1	1	531	867	62.2%	95.4%	3.18	0.75	95.4	99.9	62.2	99.9
	2		579	86.1%	88.9%	2.30	0.87	88.9	99.9	86.1	99.9
	3		918	60.4%	96.8%	3.28	0.74	96.8	99.9	60.4	99.9
	4		662	82.4%	94.2%	2.40	0.89	94.2	99.9	82.4	99.9
	5		909	60.8%	96.8%	3.26	0.75	96.8	99.9	60.8	99.9
	6		651	83.1%	94.0%	2.38	0.88	94.0	99.9	83.1	99.9
2	7	531	1,048	48.9%	96.4%	4.07	0.65	96.4	99.8	48.9	99.9
	8		613	81.6%	94.2%	2.43	0.87	94.2	99.9	81.6	99.9
	9		1,096	47.4%	97.7%	4.19	0.64	97.7	99.8	47.4	99.9
	10		670	76.7%	96.8%	2.59	0.86	96.8	99.9	76.7	99.9
	11		1,087	47.7%	97.7%	4.15	0.64	97.7	99.8	47.7	99.9
	12		661	77.8%	96.8%	2.55	0.86	96.8	99.9	77.8	99.9
3	13	519	1,225	41.4%	97.9%	4.67	0.58	97.9	99.7	41.4	99.9
	14		650	77.4%	96.9%	2.50	0.86	96.9	99.9	77.4	99.9
	15		1,279	40.0%	98.5%	4.84	0.57	98.5	99.7	40.0	99.9
	16		708	71.8%	97.9%	2.70	0.83	97.9	99.9	71.8	99.9
	17		1,268	40.3%	98.4%	4.80	0.57	98.4	99.7	40.3	99.9
	18		697	72.9%	97.9%	2.66	0.84	97.9	99.9	72.9	99.9

Alg., algorithm; MCHP, Manitoba Centre for Health Policy; sens, sensitivity; spec, specificity.