Table 3.
Incidence of microalbuminuria in subjects in different HOMA-IR quartiles, according to their glycemic and blood pressure control
| HOMA-IR quartile at baseline | Development of microalbuminuria (n) | Person-years observed | Microalbuminuria incidence per 1,000 | Incident RR (95% CI) | P value* |
|---|---|---|---|---|---|
| Overall subjects (n = 738) | |||||
| Quartile 1 | 50 | 771.6 | 64.8 | 1.00 | <0.001 |
| Quartile 2 | 62 | 742.0 | 83.5 | 1.28 (0.88–1.87) | |
| Quartile 3 | 66 | 716.2 | 92.1 | 1.42 (0.98–2.06) | |
| Quartile 4 | 69 | 696.9 | 99.0 | 1.52 (1.06–2.20) | |
| Cumulative average HbA1c ≤ 8% (n = 403) | |||||
| Quartile 1 | 27 | 501.2 | 53.8 | 1.00 | 0.657 |
| Quartile 2 | 28 | 452.3 | 61.9 | 1.14 (0.67–1.96) | |
| Quartile 3 | 35 | 371.6 | 94.1 | 1.74 (1.05–2.91) | |
| Quartile 4 | 24 | 336.9 | 71.2 | 1.32 (0.75–2.30) | |
| Cumulative average HbA1c >8% (n = 335) | |||||
| Quartile 1 | 23 | 270.4 | 85.0 | 1.00 | 0.043 |
| Quartile 2 | 34 | 289.7 | 117.4 | 1.38 (0.81–2.37) | |
| Quartile 3 | 38 | 344.6 | 110.3 | 1.29 (0.77–2.20) | |
| Quartile 4 | 45 | 360.0 | 125.0 | 1.47 (0.89–2.46) | |
| Cumulative average BP ≤130/80 mmHg (n = 290) | |||||
| Quartile 1 | 23 | 461.9 | 49.7 | 1.00 | 0.021 |
| Quartile 2 | 22 | 283.6 | 77.5 | 1.55 (0.86–2.81) | |
| Quartile 3 | 25 | 284.6 | 87.8 | 1.76 (0.99–3.13) | |
| Quartile 4 | 28 | 293.2 | 95.5 | 1.91 (1.10–3.36) | |
| Cumulative average BP >130/80 mmHg (n = 448) | |||||
| Quartile 1 | 27 | 309.7 | 87.1 | 1.00 | 0.049 |
| Quartile 2 | 40 | 458.4 | 87.2 | 1.00 (0.61–1.64) | |
| Quartile 3 | 41 | 431.6 | 95.0 | 1.09 (0.67–1.79) | |
| Quartile 4 | 41 | 403.7 | 101.6 | 1.16 (0.71–1.91) |
BP, blood pressure; RR, rate ratio.
*Test for trend for incidence rate ratio from HOMA-IR Q1 to Q4.