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. 2011 Mar 22;60(4):1100–1110. doi: 10.2337/db10-1353

FIG. 6.

FIG. 6.

CD36KO peritoneal macrophages do not migrate in response to adipocyte-derived chemotactic factors. A: Wild-type (WT) and CD36KO peritoneal macrophages were placed in transwell inserts with an 8 μmol/L porous membrane and incubated with conditioned media from vehicle, oxLDL, or AGE-treated primary adipocytes for 16 h. Macrophages that migrated to the other side of the membrane were stained and counted; each replicate is the average of four fields. B: WT and CD36KO peritoneal macrophages were treated with vehicle, oxLDL, or MCP-1 for 18 h. Macrophages attached to the cell culture plate were stained with PKH dye and fluorescence quantified. All data are expressed as means ± SE. A: n = 4; B: n = 6–15. *P < 0.05 treatment vs. vehicle; #P < 0.05 WT vs. CD36KO; two-way ANOVA with post hoc analysis.