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. 2011 Mar 22;60(4):1134–1145. doi: 10.2337/db09-1323

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — A model illustrating the role of p38MAPK in liver stress-induced insulin resistance. Stress-induced p38MAPK activation is upstream to ErbB receptors transactivation and leads to IRS-1 Ser phosphorylation and insulin signaling desensitization. Stress-induced IRS-1 Ser phosphorylation can be mediated by additional pathways that activate various IRS-1 kinases and may possibly be associated with intracellular ROS generation.