FIG. 4.

Central injection of AICAR increases food intake in p53 KO mice. A: Effects of intracerebroventricular AICAR injection (3 μg/mouse) on food intake after 6 h in p53 KO mice. B and C: Hypothalamic protein levels of pAMPK, pACC, AMPKα1, AMPKα2, ACCα, and FAS after 6 h of AICAR injection. Values were normalized to those of the internal control β-actin, and the results are expressed as arbitrary units. Mean values were obtained from six animals per group. Values are the mean ± SEM, *P < 0.05.