FIG. 5.

Reduced β-cell proliferation in p44tg mice. β-Cell proliferation was assessed by coimmunostaining for BrdU (A, green) and pHH3 (B, green) with insulin (red) and DAPI (blue) in pancreas sections from control and p44tg mice at 3 and 12–14 months of age as described in research design and methods. A representative islet for each group at magnification 40× is presented (n = 5). Quantification is shown on the right. *P < 0.05 for p44tg vs. control mice. #P < 0.05 for 3- vs. 12- to 14-month-old control mice. (A high-quality digital representation of this figure is available in the online issue.)