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. 2011 Mar 22;60(4):1246–1257. doi: 10.2337/db10-1338

FIG. 1.

FIG. 1.

SL-induced impaired insulin secretion in Gck+/− mice. A: Experimental protocol. Both the wild-type (WT) and Gck+/− mice were fed standard chow diet until 8 weeks of age and then given free access to the experimental diets. Experiments were performed on wild-type and Gck+/− mice after 25 weeks on the SO (□) or SL (■) diet. B: Insulin tolerance (n = 10–12). C and D: Glucose tolerance (n = 10–12). C: Plasma glucose levels. ○, wild-type mice on SO diet; ●, wild-type mice on SL diet; △, Gck+/− mice on SO diet; ▲, Gck+/− mice on SL diet. D: Serum insulin levels. *P < 0.05.