TABLE 1.
Effects of experimental diets at week 25 on body weight, liver weight, epididymal fat weight, blood glucose level, and serum insulin concentration after a 16-h fast in wild-type and Gck+/− mice
| Wild-type |
Gck+/− |
|||
|---|---|---|---|---|
| SO | SL | SO | SL | |
| Body weight (g) | 41.00 ± 2.39 | 39.67 ± 2.39 | 40.67 ± 2.38 | 41.60 ± 1.61 |
| Liver weight (g) | 1.87 ± 0.20 | 1.67 ± 0.15 | 2.43 ± 0.34 | 1.87 ± 0.15 |
| Epididymal fat weight (g) | 0.98 ± 0.15 | 0.89 ± 0.26 | 1.18 ± 0.19 | 1.74 ± 0.21 |
| Liver weight/body weight (%) | 4.55 ± 0.40 | 4.21 ± 0.28 | 5.87 ± 0.51* | 4.48 ± 0.25 |
| Epididymal fat weight/body weight (%) | 2.36 ± 0.29 | 2.15 ± 0.58 | 2.86 ± 0.35 | 4.24 ± 0.60† |
| Glucose (mg/dL) | 114 ± 3‡ | 110 ± 4‡ | 178 ± 9 | 181 ± 6 |
| Insulin (ng/mL) | 0.68 ± 0.038 | 0.65 ± 0.048 | 0.69 ± 0.036 | 0.76 ± 0.059 |
Data are means ± SE. n = 8–10.
*P < 0.05 relative to wild-type SL and Gck+/− SL.
†P < 0.05 relative to wild-type SO, wild-type SL, and Gck+/− SO.
‡P < 0.05 relative to Gck+/− SO and Gck+/− SL.