Table 2.

Effect of STE12a and STE12α on the activity of phospholipase and SOD

Strains†	Index of phospholipase activity‡	SOD activity§
STE12a	0.49  ± 0.01**	9.76  ± 0.05**
Δste12a	0.63  ± 0.03	14.71  ± 0.06
Δste12a∷STE12a	0.53  ± 0.03*	8.69  ± 0.04**
STE12α	0.50  ± 0.03**	7.05  ± 0.03**
Δste12α	0.97  ± 0.03	12.39  ± 0.08
Δste12α∷STE12α	0.61  ± 0.03**	7.57  ± 0.03**

^† STE12a (B4476), Δste12a (C429), Δste12a∷STE12a (C449), STE12α (B4500), Δste12α (TYCC245F1), and Δste12α∷STE12α (TYCC409AF1). 

^‡ There is an inverse relationship between index and enzyme activity, the smaller the index the higher the enzyme activity of the strain (see Materials and Methods). Data represent mean ± SD of three samples. *, P < 0.05 compared with the congenic deletant. **, P < 0.01 compared with the congenic deletant. 

^§ Bovine erythrocyte SOD was used as the standard for calibration of C. neoformans SOD activity. Data represent mean ± SD of three samples. **, P < 0.01 compared with the congenic deletant.