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. 2011 Mar 22;60(4):1314–1323. doi: 10.2337/db10-1557

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — miR-200b alteration present in human diabetic retinopathy. A: LNA-ISH study of retinal tissues from nondiabetic human retina shows localization of miR-200b in the cells of the inner nuclear layer (arrowheads) and retinal capillaries (arrow). The inset (right) shows an enlarged view of the same capillary with endothelial localization of miR-200b (blue chromogen, arrow) and CD34 stain (brown chromogen) from an adjacent section showing endothelium of the capillary. B: Retinal tissues in a diabetic human retina (in similar orientation) show minimal (if any) expression of miR-200b. C: Immunocytochemical stain on the nondiabetic human retina using antialbumin antibody shows intravascular albumin (arrow). D: Diabetic human retina showed intravascular albumin staining (arrow) and diffuse staining of the retina, indicating increased vascular permeability. (ALK Phos was used as chromogen [blue] with no counterstain in LNA-ISH; DAB chromogen [brown] and hematoxylin counterstain in albumin stain.) (Original magnification ×400.) (A high-quality digital representation of this figure is available in the online issue.)