TABLE 2.

Heart rates and systolic and diastolic blood pressures^*

Time (min)	Mixed meal		Glimepiride
	Placebo	Diazoxide	Placebo	Diazoxide
Heart rate (bpm)
−60	69 ± 4	71 ± 2	70 ± 4	71 ± 3
−30	70 ± 3	70 ± 3	72 ± 4	70 ± 3
0	73 ± 4	77 ± 3	69 ± 4	70 ± 4
30	79 ± 5	86 ± 4	68 ± 4	73 ± 4
60	78 ± 5	81 ± 4	67 ± 5	78 ± 4
90	77 ± 4	84 ± 4	68 ± 4	74 ± 3
120	77 ± 6	85 ± 4	69 ± 5	77 ± 4
150	76 ± 5	80 ± 4	70 ± 4	77 ± 4
180	74 ± 5	81 ± 4	75 ± 4	84 ± 4
	(P < 0.0001)		(P < 0.0001)
Systolic blood pressure (mmHg)
−60	118 ± 2	121 ± 3	118 ± 2	118 ± 3
−30	116 ± 3	121 ± 3	122 ± 2	126 ± 3
0	120 ± 3	121 ± 3	122 ± 2	118 ± 2
30	118 ± 3	118 ± 3	119 ± 2	118 ± 2
60	119 ± 3	117 ± 3	120 ± 2	118 ± 2
90	116 ± 3	117 ± 3	119 ± 2	115 ± 3
120	116 ± 3	114 ± 2	122 ± 3	114 ± 2
150	115 ± 3	112 ± 3	119 ± 3	115 ± 3
180	118 ± 3	113 ± 3	122 ± 3	114 ± 3
	(P = 0.2173)		(P < 0.0001)
Diastolic blood pressure (mmHg)
−60	65 ± 2	68 ± 2	69 ± 2	68 ± 2
−30	66 ± 2	69 ± 2	68 ± 1	73 ± 3
0	65 ± 3	67 ± 2	66 ± 2	68 ± 2
30	61 ± 3	58 ± 2	65 ± 2	66 ± 2
60	60 ± 2	59 ± 3	68 ± 2	61 ± 3
90	58 ± 2	60 ± 2	65 ± 2	60 ± 3
120	62 ± 2	57 ± 2	66 ± 2	60 ± 2
150	63 ± 2	58 ± 3	68 ± 2	59 ± 3
180	62 ± 2	57 ± 2	66 ± 2	60 ± 3
	(P = 0.0339)		(P < 0.0001)

*Mean ± SE data are shown after oral administration of placebo or diazoxide (6.0 mg/kg) at −30 min and a mixed meal (Ensure Plus) at 0 min on two occasions (left) or oral glimepiride (4.0 mg) on another two occasions (right) in healthy humans.