TABLE 1.
Type 2 diabetes risk loci genotyped in DPP participants
| Genetic locus | SNP typed | Alleles (risk/other) | Strand | OR* | Study | Overall study (all ethnic groups) |
||
|---|---|---|---|---|---|---|---|---|
| A = risk allele/a = other allele | ||||||||
| AA |
Aa |
aa |
||||||
| N (%) | N (%) | N (%) | ||||||
| TCF7L2 | rs7903146 | T/C | + | 1.37 | DIAGRAM | 287 (9.6) | 1,227 (41.1) | 1,469 (49.3) |
| CDKN2A/2B | rs10811661 | T/C | + | 1.26 | DIAGRAM | 2,245 (75.3) | 664 (22.3) | 71 (2.4) |
| CDKAL1 | rs7754840 | C/G | + | 1.25 | DIAGRAM | 453 (15.2) | 1,348 (45.2) | 1,180 (39.6) |
| PPARG | rs1801282 | C/G | + | 1.18 | DIAGRAM | 2,501 (83.6) | 476 (15.9) | 16 (0.5) |
| HHEX | rs1111875 | C/T | – | 1.17 | DIAGRAM | 1,218 (40.8) | 1,337 (44.8) | 432 (14.5) |
| IGF2BP2 | rs1470579 | C/A | + | 1.17 | DIAGRAM | 598 (20.2) | 1,185 (40.1) | 1,175 (39.7) |
| KCNJ11 | rs5219 | T/C | + | 1.16 | DIAGRAM | 318 (10.6) | 1,242 (41.6) | 1,426 (47.8) |
| SLC30A8 | rs13266634 | C/T | + | 1.15 | DIAGRAM | 1,723 (57.7) | 1,072 (35.9) | 191 (6.4) |
| THADA | rs7578597 | A/G | – | 1.15 | DIAGRAM | 2,259 (77.7) | 587 (20.2) | 63 (2.2) |
| CENTD2 | rs1552224 | A/C | – | 1.14 | DIAGRAM+ | 2,363 (81.9) | 494 (17.1) | 29 (1.0) |
| NOTCH2 | rs10923931 | T/G | + | 1.13 | DIAGRAM | 95 (3.3) | 697 (24.0) | 2,118 (72.8) |
| ADCY5 | rs11708067 | A/G | + | 1.12 | MAGIC | 1,891 (65.7) | 863 (30.0) | 125 (4.3) |
| WFS1 | rs10010131 | G/A | + | 1.11 | DIAGRAM | 1,315 (44.0) | 1,302 (43.6) | 371 (12.4) |
| CDC123 | rs4747969 | C/T | + | 1.11 | DIAGRAM | 136 (4.7) | 959 (33.0) | 1,814 (62.4) |
| IRS1 | rs7578326 | A/G | + | 1.11 | DIAGRAM+ | 1,299 (47.1) | 1,119 (40.6) | 340 (12.3) |
| CHCHD9 | rs13292136 | C/T | + | 1.11 | DIAGRAM+ | 2,431 (85.5) | 389 (13.7) | 25 (0.9) |
| JAZF1 | rs864745 | G/A | + | 1.10 | DIAGRAM | 493 (17.0) | 1,348 (46.5) | 1,059 (36.5) |
| HNF1B | rs757210 | T/C | – | 1.10 | DIAGRAM | 517 (17.9) | 1,318 (45.7) | 1,049 (36.4) |
| HMGA2 | rs1531343 | C/G | + | 1.10 | DIAGRAM+ | 114 (4.1) | 692 (24.8) | 1,987 (71.1) |
| ADAMTS9 | rs4607103 | C/T | + | 1.09 | DIAGRAM | 1,478 (50.8) | 1,201 (41.3) | 230 (7.9) |
| TSPAN8 | rs7961581 | C/T | + | 1.09 | DIAGRAM | 217 (7.5) | 1,089 (37.4) | 1,603 (55.1) |
| MTNR1B | rs10830963 | G/C | + | 1.09 | MAGIC | 200 (6.9) | 998 (34.5) | 1,692 (58.6) |
| BCL11A | rs243021 | A/G | – | 1.08 | DIAGRAM+ | 704 (24.4) | 1,392 (48.3) | 787 (27.3) |
| SLC22A18AS | rs231362 | G/A | – | 1.08 | DIAGRAM+ | 1,150 (40.3) | 1,274 (44.7) | 427 (15.0) |
| ZBED3 | rs4457053 | G/A | + | 1.08 | DIAGRAM+ | 251 (8.8) | 1,148 (40.3) | 1,447 (50.8) |
| PROX1 | rs340874 | C/T | – | 1.07 | MAGIC | 630 (22.1) | 1,305 (45.7) | 921 (32.3) |
| GCK | rs917793 | T/A | – | 1.07 | MAGIC | 168 (5.8) | 1,015 (35.1) | 1,707 (59.1) |
| TSGA13 | rs972283 | G/A | + | 1.07 | DIAGRAM+ | 1,099 (38.8) | 1,274 (45.0) | 460 (16.2) |
| VPS33B | rs8042680 | A/C | + | 1.07 | DIAGRAM+ | 978 (34.4) | 1,086 (38.2) | 783 (27.5) |
| HNF1A | rs7957197 | T/A | + | 1.07 | DIAGRAM+ | 2,009 (70.3) | 756 (26.5) | 92 (3.2) |
| DGKB | rs2191349 | T/G | + | 1.06 | MAGIC | 870 (30.1) | 1,401 (48.5) | 618 (21.4) |
| GCKR | rs780094 | C/T | – | 1.06 | MAGIC | 1,258 (43.5) | 1,281 (44.3) | 351 (12.2) |
| PLEKHF2 | rs896854 | T/C | – | 1.06 | DIAGRAM+ | 826 (29.0) | 1,379 (48.4) | 644 (22.6) |
| BCL2A1 | rs11634397 | G/A | + | 1.06 | DIAGRAM+ | 988 (34.3) | 1,348 (46.7) | 548 (19.0) |
OR, odds ratio.
*OR reported by previous literature (column study).