TABLE 3.
Associations between GRS and insulin secretion or insulin sensitivity indices adjusted for age, sex, ethnic background, and waist circumference in DPP participants
| Quartile of weighted GRS |
β* (SE) | P | ||||
|---|---|---|---|---|---|---|
| 1st |
2nd | 3rd | 4th | |||
| N | 710 | 711 | 711 | 711 | ||
| Weighted genetic score | 32 (24–34) | 36 (34–37) | 38 (37–40) | 42 (40–51) | ||
| Insulinogenic index | 1.24 (1.17–1.32) | 1.25 (1.18–1.33) | 1.25 (1.17–1.32) | 1.12 (1.05–1.20) | −0.004 (0.001) | <0.001 |
| ISI (= 1/HOMA-IR) | 0.157 (0.150–0.164) | 0.157 (0.150–0.164) | 0.159 (0.152–0.166) | 0.161 (0.154–0.169) | 0.006 (0.002) | 0.02 |
| Proinsulin-to-insulin ratio | 0.178 (0.170–0.186) | 0.181 (0.173–0.189) | 0.184 (0.176–0.192) | 0.191 (0.182–0.200) | 0.008 (0.002) | 0.001 |
| Disposition index (oral) | 0.048 (0.046–0.051) | 0.050 (0.047–0.053) | 0.050 (0.047–0.053) | 0.046 (0.043–0.049) | −0.004 (0.002) | 0.06 |
Data are least squares mean (95% CI) unless otherwise indicated. P values for β in the regression model. HOMA-IR, homeostasis model assessment of insulin resistance.
*Regression model, per unit increase in GRS.