TABLE 4.

Multivariable models to predict progression to diabetes in DPP participants

	Minimally adjusted for treatment arms		Multiadjusted model
Variables	HR (95% CI)	P	HR (95% CI)	P
Weighted GRS (per risk allele)	1.02 (1.00–1.04)	0.08	1.02 (1.00–1.05)	0.03
Metformin (vs. placebo)	0.71 (0.59–0.86)	0.0005	0.70 (0.58–0.85)	0.0003
Lifestyle (vs. placebo)	0.46 (0.37–0.57)	<0.0001	0.45 (0.36–0.56)	<0.0001
Female (vs. male)			0.99 (0.83–1.19)	0.94
African American (vs. white)			1.03 (0.82–1.29)	0.81
Hispanic (vs. white)			1.12 (0.88–1.42)	0.37
Asian/Pacific Islander (vs. white)			1.56 (1.04–2.33)	0.03
American Indian (vs. white)			0.90 (0.53–1.54)	0.70
Age at randomization (per year)			1.00 (1.00–1.01)	0.45
Waist circumference (per cm)			1.02 (1.02–1.03)	<0.0001