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. 2011 Mar 22;60(4):1354–1359. doi: 10.2337/db10-0885

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — A single genetic locus primarily contributes to B6.H2^g7 susceptibility to AI4 T-cell–induced diabetes. Whole genome (A) and chromosome 11–specific (B) LOD score analysis of SNP markers linked to diabetes susceptibility and insulitis severity in sublethally irradiated BC1 recipients of 1 × 10⁷ NOD.Rag1^null.AI4 splenocytes. Horizontal lines depict LOD scores indicative of 1, 5, 10, and 63% linkage support thresholds. The 1 and 63% thresholds, respectively, indicate significant and suggestive linkage. The lower bold line indicates the 95% CI for linkage. C: Schematic representation of the distal region of chromosome 11. The positions of the markers (Mb) are based on NCBI build 37. The distance between markers is not drawn to scale.