FIGURE 4.

Binding pose of compound 1. A, SigmaA-weighted omit maps showing the volunteer 2F_o − F_c 1 σ (blue) and F_o − F_c 3 σ (green) electron density for compound 1. B, hydrophobic interactions with the tricyclic core of compound 1 showing side chains of c-Met residues within 4 Å of the inhibitor (teal). C, polar interactions include a direct hydrogen bond with the Arg-1086 main chain carbonyl oxygen and several water-mediated hydrogen bonds, including one with Asp-1164. Water molecules are shown as red spheres. Compound 1 is shown in yellow, except the nitrogen and oxygen atoms are blue and red, respectively.