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. 2010 Dec 22;300(3):R693–R699. doi: 10.1152/ajpregu.00481.2010

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Fig. 1. — A: effects of chronic E₂ exposure on estrous cyclicity indicated as % of animals that showed regular estrous cycles. Adult young (4- to 5-mo old) sham implanted (control) and 30 (E-30), 60 (E-60), or 90 (E-90)-day slow release E₂ pellets implanted rats and old constant estrous (OCE) rats that are 15- to 19-mo old were used. B: serum E2 levels (means ± SE; pg/ml) in young (4- to 5-mo old) sham implanted (control) and 30 (E-30), 60 (E-60), or 90 (E-90) day slow-release E₂ pellet-implanted rats and OCE rats that are 16- to 18-mo old. *Significant difference from control animals (P < 0.05).