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Mice lacking CHOP have increased lung permeability in response to hyperoxia. A–D: bronchoalveolar lavage fluid (BALF) total protein concentration, BALF IgM concentration, lung weight normalized to starting body weight, and BALF polymorphonuclear (neutrophil) cell count in Ddit3−/− and wild-type (WT) mice exposed to 72 h of normoxia (21% O2) or hyperoxia (95% O2). E: survival of Ddit3−/− and WT mice exposed to 80% O2 for up to 10 days. *P < 0.05 vs. 21% O2.
