Table 3.
Common toxicities: The number of episodes that occurred after all vaccinations
| Toxicity | Grade 1 | Grade 2 | Grade 3 |
|---|---|---|---|
| Local skin reaction | 2 | 111 | 0 |
| Rash (not at vaccine site) | 1 | 3 | 0 |
| Arthralgias | 2 | 3 | 0 |
| Constipation | 3 | 0 | 0 |
| Cough | 4 | 0 | 0 |
| Diarrhea | 1 | 0 | 0 |
| Fatigue | 21 | 9 | 0 |
| Fever | 14 | 10 | 0 |
| Headache | 21 | 5 | 0 |
| Myalgias | 38 | 6 | 0 |
| Nausea | 5 | 0 | 0 |
| Vomiting | 1 | 1 | 0 |
| Rigors/chills | 13 | 0 | 0 |
| Pruritis | 13 | 1 | 0 |
| Increase in amylase | 2 | 0 | 1 |
| Leukopenia | 7 | 2* | 0 |
| Neutropenia | 3 | 1† | 0 |
| Lymphopenia | 4 | 13‡ | 9§ |
| Anemia | 5 | 0 | 1¶ |
| Thrombocytopenia | 5 | 0 | 0 |
Total number of vaccinations: 134.
*
Both patients had pretreatment grade 1 values.
†
This patient had a pretreatment grade 1 value.
‡
Twelve patients had pretreatment grade 2 values.
§
Six patients had pretreatment grade 3 values; 3 patients had pretreatment grade 2 values.
¶
This patient had a pretreatment grade 3 value.