Table 1.
Time Point | Control | Radiated | Significance (P value) |
---|---|---|---|
Baseline | 27.4 ± 0.5 (29) | 27.7 ± 0.4 (16) | NS (0.590) |
18 Gy | 28.7 ± 0.5 (29) | 25.7 ± 1.2 (16) | (0.008)** |
36 Gy | 29.0 ± 0.5 (29) | 25.3 ± 1.0 (16) | (<0.001)*** |
1 mo post-WBRT | 29.3 ± 0.5 (29) | 26.2 ± 1.3 (16) | (0.006)** |
End of study | |||
Normoxia | 30.0 ± 0.7 (13) | 28.3 ± 1.0 (8) | NS (0.157) |
Hypoxia | 28.6 ± 0.6 (16) | 27.1 ± 0.4 (8) | NS (0.133) |
Data represent means ± SE; for control and radiated groups, no. of animals is in parentheses. Animals were selected for body mass measurement at each major step of the experiment. Time points shown represent: before commencement of whole brain radiation therapy (WBRT) (baseline), after a cumulative dose of 18 Gy, after completion of the cumulative series of irradiation (36 Gy), 1 mo post-WBRT, and at the end of the hypoxia or normoxia treatment. NS, not significant.
P < 0.01 and
P < 0.001.