Fig. 1.
Changes in diameter of coronary arterioles isolated from patients without diabetes mellitus (DM−, n = 11) and patients with DM (DM+, n = 10) in response to cumulative concentrations of ACh in the absence (A) or in the presence (B, n = 6 in each group) of nitric oxide synthesis inhibitor NG-nitro-l-arginine methyl ester (l-NAME). Changes in diameter of coronary arterioles isolated from subjects without (DM−, n = 9) and with diabetes (DM+, n = 8) in response to cumulative concentrations of sodium nitroprusside (SNP; C) are shown. Data are means ± SE. *P < 0.05, significant changes in diameter from the baseline diameters on A and B.