Fig. 3.

Serial effects (means ± SE) of ETx with or without PA mAb compared with controls on HR (A), coronary flow (B), LVDP (C), RPP (D), LV dP/dt_max (E), and LV dP/dt_min (F) in a recirculating model. In this model, hearts were exposed to toxin and treatment throughout the entire perfusion period. Levels of significance are shown for the overall effect of toxin with placebo versus control (no toxin) and versus toxin with PA mAb (p^α) and the interaction between these effects and time (p^β). As described in materials and methods, for statistical analysis serial changes from baseline with ETx with or without PA mAb were compared with serial changes from baseline in controls. However, for clarity in A–F, the serial effects of ETx alone or with treatment (i.e., toxin with or without PA mAb minus control) are shown.